HotHardware.com tested Intel's new 45nm Core 2 Extreme QX9650 processors on the Asus P5W64WS Pro motherboard:

As you can see in the POST screen , the motherboard is in fact requesting a BIOS update for the proper CPU microcode, but after a simple strike of the F1 key the board boots flawlessly and we've been running benchmarks on a Vista installation for a week or so successfully and without incident. In the bottom right hand screen shot, we're showing a CPU-Z identification of the motherboard chipset that was taken alongside the large CPU identification shot above. As you'll note, we're running the standard 1,333MHz FSB for the chip, based on a quad-pumped 333MHz base frequency. We should note, however, that the board does not have the necessary memory dividers to run memory at standard frequencies, so there will be some memory overclocking (or underclocking) going on.