On March 1st, Microsoft released a brand new update for Windows 10 that brought a number of quality improvements. However, and after various reports, Microsoft has confirmed that this latest update can degrade graphics and mouse performance in certain games (like for example Destiny 2). Microsoft claimed that it's currently working on a resolution and will provide an update in an upcoming release. Still, and as a workaround, PC gamers can uninstall KB4482887 to regain performance. Microsoft has not explained/detailed the reasons behind this performance degradation. Moreover, this issue may not affect everyone therefore I strongly suggest uninstalling this update only if you are experiencing worse performance in your favourite games after applying it.

Update: As discovered by WindowsLatest, Microsoft has updated the KB4482887 support page to add two additional known issues that address performance degradation, as well as an issue with using MSI or MSP files, they are as follows:

Symptom	Workaround
After installing this update, users may receive “Error 1309” while installing or uninstalling certain types of MSI and MSP files.	Ignore the error. Microsoft is working on a resolution and will provide an update in an upcoming release.
After installing KB4482887, users may notice graphics and mouse performance degradation with desktop gaming when playing certain games (eg: Destiny 2).	Microsoft is working on a resolution and will provide an update in an upcoming release. As a short-term resolution, users can uninstall KB4482887 to regain performance.

Microsoft suggests that users ignore the Error 1309 message, which will be fixed "in an upcoming release", as for the graphics and mouse issues in certain games like Destiny 2, the company advises that users uninstall the KB4482887 update as a short-term solution if they can't wait for an update. To uninstall the KB4482887 update, open Settings (from the Start menu, or 'All settings' from the action center slide out) select Update & Security, then click on the "View update history" link on the Windows Update page, then the "Uninstall updates" link; the classic Control Panel will open, after which you can select the KB4482887 update and right click to uninstall it.